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Intercellulaire signalling in eukaryotes is a key factor which regulates not only gene expression but also cell motility, differentiation, division and programmed death. Our aim is to better understand the role of the mitogen activated MAP-kinases and the Stress Activated SAP-kinases cascades in transducing intercellular signals during embryonic development and in cancer.

The enhancesome, a nucleoprotein structure formed by the ribosomal transcription factor UBF binding to the ribosomal DNA. An electronmicrograph obtained by electron spectroscopic imaging. The enhancesome is the target of structual regulation by acetyltransferase CBP, the retinoblastoma protein Rb, cyclin dependent kinases CDK2/4 and MAP-kinase. The DNA, in yellow and red, is folded into a single loop of about 16nm diameter containing about 140 base pairs, suggesting that UBF induces a specialised ribosomal chromatin implicated in gene activation.