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Gene Expression: Relevant Publications

UV laser induced protein-DNA crosslinking. Dimitrov S.I. & Moss T., (1994) Methods in Molecular Biology, Vol. 30: DNA-Protein Interactions: Principles and Protocols, Chapter 18, p.227-236, Editor G. Kneale, Humana Press, Towota, NJ.

Short range DNA looping by the Xenopus HMG-box transcription factor xUBF. Bazett-Jones D.P., Leblanc B., Herfort M. and Moss T., (1994) Science, 264, 1134-1137.

Promotion and regulation of ribosomal transcription in eukaryotes by RNA polymerase I. Moss T. and Stefanovsky V., (1995) Prog. Nucl. Acids Res. Mol. Biol., 50, p.25-66. Download PDF version.

Over-expression of the transcription factor, UBF1, is sufficient to increase rDNA transcription in neonatal cardiomyocytes: Implications for cardiac hypertrophy. Hannan R.D.#, Stefanovsky V.*#, Taylor L., Moss T*. and Rothblum L.I., (1996) PNAS 93, 8750-8755.

The DNA supercoiling architecture induced by the transcription factor xUBF requires three of its five HMG-boxes. Stefanovsky V.*, Bazett-Jones D.P., Pelletier, G.* and Moss T.*, (1996) Nucl. Acids Res. 24, 3208-3215.

Laser-based UV crosslinking of proteins to DNA. Dimitrov S.I.*, Houde D. and Moss T.*, (1997), in Methods: A Companion to Methods in Enzymology " In vivo footprinting analysis of protein-nucleic acid interactions", Ed. K. Zaret, 11, 225-234.

The structural and architectural role of upstream binding factor, UBF. Moss T., Stefanovsky V. Y. and Pelletier G., (1998), in "RNA Polymerase I: Transcription of eukaryotic ribosomal RNA", Ed. M. Paule R.G., Landes Company, Georgetown, Texas. Download PDF version.

Affinity purification of mammalian RNA polymerase I - Identification of an associated kinase. Hannan, R.D., Hempel W.M., Cavanaugh A., Arino T., Dimitrov S.I. *, Moss T. *, and Rothblum L. (1998) J. Biol Chem. 273, 1257-1267.

Cellular regulation of Ribosomal DNA Transcription: Both Rat and Xenopus UBF1 Stimulate rDNA Transcription in 3T3 Fibroblasts. Hannan R., Stefanovsky V.*, Arino T., Rothblum L. I., and Moss T.* (1999) Nucl. Acids Res. 27, 1205-1213.

A ribosomal orphon sequence from Xenopus laevis flanked by novel low copy number repetitive elements. Guimond A. and Moss T. (1999) Biol. Chem. 380, 167-174.

Identification of a mammalian RNA polymerase I holoenzyme containing components of the DNA repair/replication system. Identification of a mammalian RNA polymerase I holoenzyme responsive to activators. Hannan R. D., Cavanaugh A., Hempel W.M., Moss T*. and Rothblum L. (1999) Nucl. Acids Res. 27, 3720-3727.

DNAase I footprinting. Leblanc B. & Moss T., (2000). Nucleic Acid Protocols Handbook, Chapter 92, Editor R. Rapley, Humana Press, Towota, NJ.

Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and Ribosomal transcription. Pelletier G., Stefanovsky V.Y., Faubladier M., Hirschler-Laszkiewicz, I., Savard J., Rothblum L.I., Coté J. and Moss T., Molecular Cell 6,1059-1066. Download PDF version.

Methods in Molecular Biology, Vol. 148, Edition 2: DNA-Protein Interactions: Principles and Protocols. Editor; T. Moss. (2001) Humana Press, Towota, NJ, in press. Click image for more information.

DNAase I footprinting. Leblanc B. & Moss T., (2001) Methods in Molecular Biology, Vol. 148, Edition 2: DNA-Protein Interactions: Principles and Protocols, Chapter 3, Editor T. Moss, Humana Press, Towota, NJ, in press.

UV laser induced protein-DNA crosslinking. Dimitrov S.I. & Moss T., (2001) Methods in Molecular Biology, Vol. 148, Edition 2: DNA-Protein Interactions: Principles and Protocols, Chapter 27, Editor T. Moss, Humana Press, Towota, NJ, in press.

DNA looping in the RNA polymerase I enhancesome is the result of non-cooperative in-phase bending by two UBF molecules. Stefanovsky, V. Y., Pelletier, G., Bazett-Jones, D. and Moss T., (2001) Nucl. Acids Res. 29, 3241-3247.

An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF. Stefanovsky, V. Y., Pelletier, G., Hannan, R., Gagnon-Kugler, T., Rothblum, L.I., and Moss T., (2001) Molecular Cell 8, 1063-1073. PDF version.

At the centre of the eukaryotic life? Moss, T and Stefanovsky V. Y. (2002), Minireview, Cell 109, 545-548. PDF version.

Gènes ribosomaux et régulation de la croissance cellulaire. Moss, T., Käs, E. and Bisson, N. (2002) Invited minireview ("Nouvelle") for Médecine/Sciences 10, 940-942. PDF version.

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and immediated by phosphorylation of the carboxy terminal activation domain of the nucleolar transcription factor UBF. Hannan K.M., Brandenburger Y., Jenkins A., Sharkey K., Cavanaugh A., Rothblum L., Moss T., Poortinga G., McArthur G.A., Pearson R.B. and Hannan R.D. (2003) Mol. Cell Biol. 23, 8862-8877.

At the crossroads of growth control; making ribosomal RNA. Moss, T. (2004) Curr. Opin. Genes Dev., in press.

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