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Recent Publications 

The Cytoskeletal Effector xPAK1 Is Expressed During Both Ear And Lateral Line Development In Xenopus. Islam N., Poitras L. and Moss T., (2000) Int. J. Dev. Biol. 44, 245-248. Download PDF version.

DNAase I footprinting. Leblanc B. & Moss T., (2000). Nucleic Acid Protocols Handbook, Chapter 92, Editor R. Rapley, Humana Press, Towota, NJ.

Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and Ribosomal transcription. Pelletier G., Stefanovsky V.Y., Faubladier M., Hirschler-Laszkiewicz, I., Savard J., Rothblum L.I., Coté J. and Moss T., (2000) Molecular Cell 6,1059-1066. Download PDF version.

Methods in Molecular Biology, Vol. 148, Edition 2: DNA-Protein Interactions: Principles and Protocols. Editor; T. Moss. (2001) Humana Press, Towota, NJ, in press. Click image for more information.

DNAase I footprinting. Leblanc B. & Moss T., (2001) Methods in Molecular Biology, Vol. 148, Edition 2: DNA-Protein Interactions: Principles and Protocols, Chapter 3, Editor T. Moss, Humana Press, Towota, NJ, in press.

UV laser induced protein-DNA crosslinking. Dimitrov S.I. & Moss T., (2001) Methods in Molecular Biology, Vol. 148, Edition 2: DNA-Protein Interactions: Principles and Protocols, Chapter 27, Editor T. Moss, Humana Press, Towota, NJ, in press.

DNA looping in the RNA polymerase I enhancesome is the result of non-cooperative in-phase bending by two UBF molecules. Stefanovsky, V. Y., Pelletier, G., Bazett-Jones, D. and Moss T., (2001) Nucl. Acids Res. 29, 3241-3247.

An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF. Stefanovsky, V. Y., Pelletier, G., Hannan, R., Gagnon-Kugler, T., Rothblum, L.I., and Moss T., (2001) Molecular Cell 8, 1063-1073. PDF version.

At the centre of the eukaryotic life? Moss, T and Stefanovsky V. Y. (2002), Minireview, Cell 109, 545-548. PDF version.

Gènes ribosomaux et régulation de la croissance cellulaire. Moss, T., Käs, E. and Bisson, N. (2002) Invited minireview ("Nouvelle") for Médecine/Sciences 10, 940-942. PDF version.

A tissue restricted role for the Xenopus jun N-terminal kinase kinase kinase MLK2 in cement gland and pronephric tubule differentiation. Poitras L., Bisson N., Islam N. and Moss, T. (2003), Developmental Biology 254, 200-214.

PAK interacts with Nck and MLK2 to regulate the activation of jun N-terminal kinase. Poitras L., Jean S., Islam N. and Moss T. (2003), FEBS-Letters 543, 129-135.

The catalytic domain of xPAK1 is sufficient to induce myosin II dependent in vivo cell fragmentation independently of other apoptotic events. Bisson, N., Islam N., Poitras L., Jean, S., Bresnick A., and Moss T. (2003), Developmental Biology 263, 264-281.

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and immediated by phosphorylation of the carboxy terminal activation domain of the nucleolar transcription factor UBF. Hannan K.M., Brandenburger Y., Jenkins A., Sharkey K., Cavanaugh A., Rothblum L., Moss T., Poortinga G., McArthur G.A., Pearson R.B. and Hannan R.D. (2003) Mol. Cell Biol. 23, 8862-8877.

At the crossroads of growth control; making ribosomal RNA. Moss, T. (2004) Curr. Opin. Genes Dev., 14, 210-217. PDF version.

Fragile X-related   protein FXR1P regulates somite formation in Xenopus laevis . Huot M-E, Bisson N. ,   Davidovic L.,   Mazroui R., Yves Labelle Y.,   Moss T. and Khandjian E.W. (2005) Mol. Biol. Cell, 16, 4350-4361.

Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals, a role for UBF phosphorylation and rchromatin remodeling. Stefanovsky V.Y., Langlois F., Gagnon-Kugler T. , Rothblum L.I. and Moss T . (2006) Mol. Cell 21, 629-639.

ERK modulates DNA bending and Enhancesome structure by phosphorylating HMG1-boxes 1 and 2 of the RNA polymerase I transcription factor UBF. Stefanovsky V.Y., Pelletier G. , Bazett-Jones D.P., and Moss T. (2006) Biochemistry 45, 3626-3634.

Regulation of rRNA synthesis in human and mouse cells is not determined by changes in active gene count. Stefanovsky V. Y. and Moss T. (2006) Cell Cycle 5, 735-739.

A new paradigm for the regulation of the mammalian ribosomal RNA genes. Moss T. Stefanovsky V.Y., Langlois F. and Gagnon-Kugler T. (2006) Biochemical Society Transactions 34, 1079-1081.

A housekeeper with power of attorney, the rRNA genes in ribosome biogenesis . Moss, T. Stefanovsky V.Y., Langlois F. and Gagnon-Kugler T.   (2007) Cell. Mol. Life Sci. 64, 29-49. PDF version.

EphA4 signalling regulates blastomere adhesion in the Xenopus embryo by recruiting Pak1 to suppress Cdc42 function. Bisson N., Poitras L., Mikryukov A., Tremblay, M. and Moss, T. (2007) Mol. Biol. Cell 18, 1030-43.

A ubiquitin conjugating enzyme, ube2d3.2, regulates xMLK2 and pronephros formation in Xenopus. Jean S. and Moss, T. Differentiation (2008) Differentiation 76, 431-441.

Lack of phenotype in mice having the mixed-lineage kinases genes Mlk1 and Mlk2 inactivated. Bisson N., Tremblay M., Robinson F., Kaplan D. R., Trusko S. P. and Moss, T. (2008) Cell Cycle 9, 909-916.

The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation. Stefanovsky V. and Moss T. (2008) Nucl. Acids Res. 36, 5093-5101. (published on-line at http://nar.oxfordjournals.org/cgi/reprint/gkn484?ijkey=F01QlPIOueiF2T4&keytype=ref)